Growth Factor Signaling Regulates Mechanical Nociception in Flies and Vertebrates

Nerve growth factor regulates nociception in human health and disease.

In this review, evidence is marshalled for the hypothesis that nerve growth factor (NGF) regulates nociception in human health and disease. The data from humans complement the studies of NGF in animal inflammatory pain models described elsewhere in this issue. An attempt is made to unify the role of NGF in inflammatory and neuropathic hyperalgesia. Although largely speculative at this stage, hu...

Evolution of nociception in vertebrates: comparative analysis of lower vertebrates.

Nociception is an important sensory system of major fundamental and clinical relevance. The nociceptive system of higher vertebrates is well studied with a wealth of information about nociceptor properties, involvement of the central nervous system and the in vivo responses to a noxious experience are already characterised. However, relatively little is known about nociception in lower vertebra...

Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.

Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and development, but they contribute to various pathological conditions when disrupted. Activation of RTKs stimulates a plethora of pathways, including the ubiquitylation and endocytosis of the receptor itself. Although endocytosis terminates RTK signaling, it has emerged as a requisite step in RTK activation...

Nitric Oxide Regulates Growth Factor Signaling in Pancreatic Cancer Cells

GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling

Glutathione S-transferases (GSTs) are the enzymes that defend cells against the damage mediated by oxidant and electrophilic carcinogens. GSTπ (GSTP1) is a member of the GST family and the hypermethylation GSTP1 CpG island DNA is detected in human hepatocellular carcinoma (HCC) tissues, which contributes to the negative expression of GSTP1 mRNA and protein. GSTP1 expression is considered to be ...